Contains no
Yeast, corn, wheat, artificial flavours or preservatives.

Cautions
Always read the label. Take only as directed. Not to be taken during pregnancy or breastfeeding. Always consult your healthcare professional if on prescription medication.

Rhodiola Rosea: This herb has been shown to help with depression, anxiety, stress, stomach issues, and many nervous system conditions. It has also proven effective in relaxing muscles and regulating blood blow, which makes it ideal for stress relief.

Lycium Barbarum: An ingredient that is known to help with a variety of health issues, including restoration of overall health and support for vision, diabetes, cancer prevention, and other ailments.

Astragalus: This ingredient is known to stimulate the immune system and act as an antioxidant to help the fight against free radicals. It helps promote overall health and wellbeing.

Rosavin: Rosavin has an anti-depressant effect in most people, as well as the ability to help improve energy and elevate the mood that can often be depleted by excessive stress.

Humulus Lupulus: This ingredient has a sedative effect, helping to regulate sleep and balance hormones in the body, as well. It can provide many areas of relief to anyone suffering from excessive stress, including support for virus and bacterial infection prevention.

Ziziphus Jujube: This herb can help with healing, exhaustion, stomach issues, and anxiety, making it a great addition to the stress relief formula.

Polygonum Multiflorum: An herb that is used to boost the immune system, improve sexual libido, assist with high blood pressure and cholesterol, and many other health ailments. It has been used for centuries in China and is becoming much more popular in recent years in supplement products.

Glycyrrhiza Uralensis: This is the technical name for licorice root, which is ideal for helping with many different health issues. It can help with immune support, anxiety, hormone production, and many areas of your bodily health that relate to stress.

Dosage

What is your recommended dosage?
We recommend 2 capsules a day.

How will I benefit from MX Stress Protect?
MX Stress Protect has been uniquely balanced and created to help support the body’s energy systems, aid in balancing health, chemicals and also to restore an overall sense of wellbeing to the body by helping with stress management and health concerns related to increased stress.

Will I see immediate results?
Some people do report immediate benefits, but usually the body requires time to build up the nutrients and restore the overall health balance. If you do not see immediate results, you should not assume that the product doesn’t work because full effects can take days or even weeks to notice.

Are there side effects with MX Stress Protect?
Generally, there are no ill effects reported with this supplement. Some people do experience nausea from time to time, but this can be alleviated by taking MX Stress Protect with food.

Can MX Stress Protect be taken with other medications or supplements?
As far as supplements are concerned, you should have no trouble taking MX Stress Protect with other supplement products. You do need to read the labels to ensure that you aren’t getting too much of any one ingredient, however. Supplements should not be taken during pregnancy or while breastfeeding.

If you are taking prescription medications or have serious health conditions, you need to talk to your doctor before taking any additional supplements. Although it is rare, some medications and health conditions can adversely affect supplementation, and vice versa. Always consult your healthcare provider before adding supplements.

Are there other ways to improve my health?
It’s important that you eat a healthy, balanced diet and incorporate exercise into your schedule on a regular basis in order to maintain optimal health. By having a healthy lifestyle, you can help your body manage stress better, in addition to taking MX Stress Protect.

What if I have questions about MX Stress Protect or other products?
Please feel free to send us an email at anytime. We’re always interested to see what our customers have to say and want to know, and we’re only a few clicks away. Just head on over to our contact page and send us a message anytime.

Customer Comments

I cannot believe what a difference this product has made to my life, I wake up in the morning happy to face a new day! I think I felt better immediately, but certainly after three months, the change is incredible.

Mary

I now feel, well, calm and balanced, it took a few weeks, but I am in control of my life again!

Edward

My friend recommended Maxalife Stress Relief as an alternative to prescription medicine, I thought I would give a few weeks trial and if I did not feel better then I would go to the doctor. Glad I did! I was suffering from mood swings, would feel great in the morning but by the time evening came around, all the pressures of the day had built up and I felt as if I was carrying a weight on my shoulders. I am now so much more positive and able to handle what comes up in the day, I return home at night happy and cheerful. Thank you, great stuff.

John

MX Stress Protect Buying Guide

Finding the right remedy for stress relief isn’t always easy. The main ingredient in MX Stress Protect is Rhodiola, which has been very closely studied and proven to help relieve stress and assist with many issues that relate to excessive stress within the body. Because of today’s fast-paced world and people’s busy lifestyles, there is little time to relax and get the proper nutrition that is needed to maintain optimal health. While some stress supplements will claim to work quite well, it is up to you to investigate your options and learn about the different ingredients that are used. With MX Stress Protect, you are getting only the best ingredients that will give you the health support that you need. Keep reading to learn more about stress, Rhodiola, and how to buy the best supplements.

Health Benefits of MX Stress Protect

The health benefits of MX Stress Protect are many. This supplement was uniquely designed to provide you with all of the health support that you need, no matter what type of stress you are under. You can get more than just a better way to manage or relieve stress with MX Stress Protect, however. Other health benefits that you can find include:

• Immune health support from the various herbs that are used to help balance your immune system and give it the nutrients that it needs
• Improved memory and concentration, thanks to ingredients like Rhodiola and others that are proven to help with your mental clarity and focus
• More energy because the body will be more in balance and the energy system will get the fuel that it needs
• Better mood with ingredients that have anti-depressant properties
• Stress management that comes from being able to have a more balanced state of mental and physical health
• Increased libido that has likely been depleted by the body’s response to stress over time
• Reduced stress because you will have more energy and feel better overall
• Better overall health, thanks to natural ingredients that are uniquely combined to cater to the specific needs of stress relief while providing residual benefits to the rest of the body.

As you can see, there are many health benefits to MX Stress Protect. Anyone who experiences even moderate stress in their life can benefit from a supplement like this because it will give them the health support that they need and deserve. You will likely be impressed with all of the residual benefits that come from our 100% natural formula of MX Stress Protect.

Statistics and Facts about Stress

Nearly 50 million people are estimated to suffer from unhealthy stress levels at work

Stress is the leading cause of high blood pressure, heart attack, and general illnesses and poor health in most people

Stress reduction is a major goal of health organizations worldwide because it has become such a prevalent health issue

Stress can lead to hair loss and other cosmetic changes

Stress-related acne accounts for almost all cases of adult acne

The top 6 causes of death are all stress-related, including heart disease, cancer, accidents, suicide, lung disease, and cirrhosis (liver disease caused by alcohol)

Stress can lead to diabetes and obesity

Stress headaches are caused by the blood flow in the body being re-routed as a response to stress

Stress can cause many digestive disorders, including ulcers, and make them more severe if untreated

Stress is commonly known as the ‘silent killer’ because of its effect on the heart and circulatory system that typically goes unnoticed until a major event occurs

Men are more likely than women to succumb to stress related hypertension, alcohol or drug abuse, and aggressive behavior

Why MX Stress Protect Works

MX Stress Protect has been carefully formulated to provide the best nutrients and herbs that will help your body reduce stress, better manage stress in the future, and restore its overall health levels. Every single ingredient was hand-selected to provide people with the exact nutrients that they need and nothing else. If you are looking for the most natural solution for stress relief, MX Stress Protect has what you need. You will enjoy stress reduction and management benefits, along with plenty of residual health benefits. MX Stress Protect Works because:

• People are too busy and preoccupied to have perfect health and healthy lifestyles. At Maxalife, we want to help people fill in the gaps and get the most from their health, including stress relief with the ingredients in MX Stress Protect.
• Maxalife has hand-picked and researched every single ingredient in our supplements, including MX Stress Protect. We do this to ensure that we create the perfect formula to give you the benefits that you need every single time.
• The ingredients in MX Stress Protect are uniquely designed to offer all of the health benefits that your body needs to manage stress and improve health issues that have been caused by stress, helping you ensure that you maintain a balance even when you can’t balance your life on your own.

Why Buy from Maxalife?

Maxalife products are always created with you in mind. Our company was founded by people who are passionate about healthy living and finding natural solutions for health issues. Every supplement that we create is made from the purest and most natural ingredients so that you get everything that you need and nothing that you don’t. Maxalife’s Stress Protect formula has been carefully created to be 100% natural, providing only the extra boost of nutrients that your body needs and nothing else.

When you buy from Maxalife, you will also enjoy our 6-month, 100% money-back guarantee. We understand that these supplements take time to work, and we’re willing to let you wait and see what happens. You will appreciate the benefits that you receive from products like MX Stress Protect over time, and if you don’t you can send them back for a full refund. You aren’t risking a thing when you buy from us because you’ll get high-quality supplements that are proven effective and a guarantee for any situation that causes you to change your mind about the products that you have purchased. When you purchase Maxalife products, you’re getting the best of everything for an affordable price, and that’s why our company is the best for natural supplements.

Purity and Freshness

MX Stress Protect and other supplements from Maxalife are created from 100% pure and natural products. We guarantee purity and freshness with all of our products, no matter what you might be looking for. Don’t just take our word for it, though. We have evidence to support our freshness and purity standards that will demonstrate just how safe and effective our supplements can be.

What Makes Maxalife MX Stress Protect So Beneficial?

Maxalife’s MX Stress Protect has everything that you need for stress relief and overall health improvements. This supplement is designed to give you everything that you need and nothing that you don’t. You will enjoy improved stress management as well as improvements in other areas of your body due to the residual effects of the ingredients in this supplement. Plus, you are getting a supplement from a company that stands behind their products and works to create the best possible health solutions for people from all walks of life, no matter what their specific health needs might be. All this is backed by our 6-month, no questions asked guarantee that you won’t find anywhere else, giving you a product that you can appreciate from a company that you can trust.

More Resources

HelpGuide.Org- Understanding Stress

Stress Management

Medline Plus

Purity
See Notes

Freshness
See Notes

Bio-Availability

Natural nutrients make all the difference in a supplement product. Bio-availability is the rate at which your body absorbs nutrients based on their molecular shape and structure. With natural herbs and nutrients like those found in MX Stress Protect, you can trust that you are getting the most nutrients for your money and the best absorption, or bio-availability, possible. When you are looking at the different types of vitamins and other minerals to support your health, you need to find the most natural solutions available, which is exactly what we offer here at Maxalife.

Synthetic products and modified compounds are not going to be as effectively absorbed by the body simply for the sheer fact that they are not completely natural. The body is used to getting nutrients in their normal, natural state and when you alter the nutrients they will have less of a chance of being absorbed. That ends up being a waste of money for you because you’re not actually able to enjoy all the benefits of the supplement products that you are using.

Leave it to Nature

At Maxalife, we like to leave things to nature. We simply take the natural vitamins and minerals in our MX Stress Protect and other supplements and combine them in the most effective manner possible. We don’t try to modify nature or make improvements because we understand that nature knows best. What good is a natural health solution, after all, if it is not so natural or effective in terms of bio-availability? It just makes sense to let nature do its job and provide you with the nutrients that your body needs in a natural, pure form.

We have the purest, most natural herbs, vitamins and minerals in our MX Stress Protect, designed to be properly absorbed by the body and provide all the benefits that people deserve. You will find no synthetic products in our supplements because we let nature do the work when it comes to helping your health through supplementation.

Pharmaceutical Grade

This is a word that some companies use in an attempt to dupe people into actually thinking that there is something better out there. When you see advertisements or products that claim to be ‘pharmaceutical grade’, you need to beware. There is no such thing in the world of supplements. The best that you can get is a 100% natural, safe and effective supplement product. Marketers who are trying to aggressively corner the industry use words like this to entice people into thinking that they are getting something better than they might get anywhere else. The reality is that their products usually aren’t even the best supplements on the market.

At Maxalife, we are committed to helping people live full, healthy lives and all of our supplements are created with that commitment in mind. We use 100% natural ingredients that are pure and as fresh as possible so that you can get the most from your supplements. We don’t need to give them a fancy label or call them something that they aren’t because we create the safest and most effective supplements and stand behind every single product that we sell.

What about Regulatory Guidelines?

There are regulatory guidelines out there, but they are way too lenient and not nearly high enough to meet our standards. Maxalife is fully focused on raising the standards of quality in the supplement world, and you can trust that you are getting the best products available when you buy from Maxalife. Because of the largely un-monitored and inconsistent guidelines that are set forth by different agencies, we have given ourselves the demand of producing high-quality supplement products that go above and beyond the ‘regulations’ as they currently stand.

At Maxalife, we perform extensive testing to ensure that our supplements are the best that they can be and we keep all of our data on file so that we can keep track of how things are doing. If you every want to see just how serious we are about quality and purity, just ask.

Specifications and COA
See Notes

Benefits and Clinical Studies

There have been many studies performed on the effectiveness of the ingredients that are used in MX Stress Protect. Studies of Rhodiola and other ingredients have proven to have many positive effects on the body, including helping with ailments and health issues like:

• Stress reduction and management
• Immune health support
• Fatigue and energy
• Depression and mental health
• Nervous system health

Find out more about the many benefits of the ingredients in MX Stress Protect by reading through the clinical studies below. You might be surprised at just how many health benefits can be found with natural ingredients like the ones in MX Stress Protect.

Clinical Studies

Lack of Effect of Rhodiola or Oxygenated Water Supplementation on Hypoxemia and Oxidative Stress

Stacie L. Wing, MS, RD1, E. Wayne Askew, PhD1, Maurie J. Luetkemeier, PhD1, Darin T. Ryujin, MS1, Gary H. Kamimori, PhD2, Colin K. Grissom, MD13

Objective

This study investigated the effects of 2 potentially “oxygen promoting” dietary supplements on hypoxia and oxidative stress at a simulated altitude of 4600m.

Methods

Fifteen volunteers (ages 20–33) received 3 separate 60-minute hypoxic exposures by breathing 13.6% oxygen at an ambient barometric pressure of 633mm Hg (simulating the partial pressure of oxygen at 4600m elevation). Each subject received, in random order, treatments of a 7-day supply of placebo, Rhodiola rosea, and an acute dose of stabilized oxygen dissolved in water. Arterialized capillary blood oxygen samples (PcO2) were measured at baseline and at 30 and 60 minutes of exposure. Pulse oximeter oxyhemoglobin saturation (SaO2) was measured at baseline and at every 10 minutes of hypoxic exposure. Oxidative stress markers measured included baseline and 60-minute exposure serum lipid peroxides (LPO) and urine malondialdehyde (MDA).

Results

For each treatment group, PcO2 decreased by approximately 38% from baseline to 60-minute hypoxic exposure. Similarly, SaO2 also decreased among groups from approximately 97 to 81%. Serum lipid peroxides increased significantly in the placebo group and decreased significantly from baseline in response to the stabilized oxygen treatment (P=.02); there was a trend for decreased LPO with the Rhodiola treatment (P=.10). There were no significant changes for MDA among groups.

Conclusions

The 2 dietary supplements investigated did not have a significant effect on blood oxygenation after 60 minutes of sedentary hypoxic exposure. Hypoxia-induced oxidative stress was observed in the control group only. Both supplements appeared not to increase oxidative stress and may decrease free radical formation after hypoxic exposure compared with the control.

Effect of Extracts from Rhodiola Rosea and Rhodiola Crenulata (Crassulaceae) Roots on ATP Content in Mitochondria of Skeletal Muscles

M. Abidov, F. Crendal, S. Grachev, R. Seifulla and T. Ziegenfuss

Abstract

We studied the effects of oral treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in rats. Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of exhaustive swimming in comparison with control rats and rats treated with R. crenulata. R. rosea extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative energy processes after intense exercise. Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity.

Rhodiola rosea in stress induced fatigue –
A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.

V. Darbinyan, A. Kteyan, A. Panossian2, E. Gabrielian2, G.Wikman3 and H. Wagner4

Summary

The aim of this study was to investigate the effect of repeated low-dose treatment with a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of 56 young, healthy physicians. The effect was measured as total mental performance calculated as Fatigue Index. The tests chosen reflect an overall level of mental fatigue, involving complex perceptive and cognitive cerebral functions, such as associative thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual perception. These parameters were tested before and after night duty during three periods of two weeks each: a) a test period of one RRE/placebo tablet daily, b) a washout period and c) a third period of one placebo/RRE tablet daily, in a double-blind cross-over trial. The perceptive and cognitive cerebral functions mentioned above were investigated using 5 different tests. A statistically significant improvement in these tests was observed in the treatment group (RRE) during the first two weeks period. No side-effects were reported for either treatment noted. These results suggest that RRE can reduce general fatigue under certain stressful conditions.

Comparative Study on 3 Kinds Different Habitas Rhodial Sachlinensis on Effect of Anti-stress of Mice

YANG Jie, SUN Yan, LI Ping1 (The General Hospital of PLA, Beijing 100853; Academy of Military Medical Science1, Beijing 100850)

To investigate the anti-stress effect of 3 kinds different habitas Rhodial Sachlinensis, adopted the Hypoxia tolerance test under ordinary pressure, low temperature test and the mice poisoned by NaNO2, is studied the comparison of 3 kinds different habitas Rhodial Sachlinensis on the anti-stress of mice. Under above-mentioned stress condition, the living time of experimental groups? mice were markedly longer than that of control groups. It is concluded that 3 kinds of different habitas Rhodial Sachlinensis could obviously improve the anti-stress effect of mice.

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Marina Perfumi, Laura Mattioli

Abstract

Rhodiola rosea L., or ‘golden root’, is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies

Volker Fintelmann and Joerg Gruenwald

Abstract

During a 12-wk drug monitoring study, the efficacy and safety of a Rhodiola rosea extract given in combination with vitamins and minerals (vigodana®) were tested in 120 adults (83 women and 37 men, ages 50–89 y) with physical and cognitive deficiencies. Two different dosage regimens were chosen. One group of 60 patients (group 1) took 2 capsules orally in the morning after breakfast, and the other group (group 2) took 1 capsule after breakfast and 1 after lunch. Three medical examinations were performed during the course of the study (at baseline, after 6 wk, and after 12 wk). The evaluated symptoms were divided into physical disturbances such as exhaustion, decreased motivation, day-time sleepiness, decreased libido, sleep disturbances, and cognitive complaints (e.g., concentration deficiencies, forgetfulness, decreased memory, susceptibility to stress, irritability). A statistically highly significant improvement (P < .001) in physical and cognitive deficiencies was observed in the overall group, as well as in the separately evaluated groups 1 and 2. In addition, the time needed to complete a digit connection test decreased significantly in all groups (P < .001). Improvements in group 1 were more pronounced than in group 2, however, indicating that the intake of 2 capsules after breakfast is more effective than the intake of 1 capsule after breakfast and 1 after lunch. Global assessment of efficacy revealed that treatment was “very good” or “good” for 81 % of patients, as reported by physicians, and for 80%, as reported by patients. Ninety-nine percent of patients and physicians rated safety as “good” or “very good.” No adverse events occurred during the course of the study. The results of this drug monitoring study are very promising, but they still need to be corroborated by future placebo-controlled clinical trials.

[Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]

Kucinskaite A, Briedis V, Savickas A.

Department of Pharmaceutical Technology and Pharmacy Organization, Kaunas University of Medicine, A. Mickeviciaus 9, 44307 Kaunas, Lithuania. agnute.ku@delfi.lt

Abstract

The paper presents a review of the scientific publications on Rhodiola rosea L. known for its adaptogenic characteristics. Biologically active substances salidroside, rosin, rosavin, rosarin and tyrosol, which are mainly found in plant rhizomes, demonstrate therapeutic effect. These active components affect the central nervous system by increasing the ability to concentrate, the mental and physical power; they are efficient in the asthenic states and improve general resistance of the cells and the organism against the harmful outer influence. They also prevent the heart system from stress and arrhythmias, and posses some antioxidant activity. Some data confirm that the Rhodiola rosea L. preparations stop the growth of the malignant tumors and metastases in the liver. Some preclinical and clinical data of the golden root preparations are discussed in the survey. The interaction of the herb with other medicines, its usage and effect, recommended doses, and its side effects are also reviewed in the paper.

The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae.

Bayliak MM, Lushchak VI.

Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76025, Ukraine.

Abstract

The effect of aqueous extract from R. rosea root on lifespan and the activity of antioxidant enzymes in budding yeast Saccharomyces cerevisiae have been studied. The supplementation of the growth medium with R. rosea extract decreased survival of exponentially growing S. cerevisiae cells under H(2)O(2)-induced oxidative stress, but increased viability and reproduction success of yeast cells in stationary phase. The extract did not significantly affect catalase activity and decreased SOD activity in chronologically aged yeast population. These results suggest that R. rosea acts as a stressor for S. cerevisiae cells, what sensitizes yeast cells to oxidative stress at exponential phase, but induces adaptation in stationary phase cells demonstrating the positive effect on yeast survival without activation of major antioxidant enzymes.

Copyright © 2011 Elsevier GmbH. All rights reserved.

PMID: 21802922 [PubMed - as supplied by publisher]

Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy.

Liu Z, Li X, Simoneau AR, Jafari M, Zi X.

Department of Urology, University of California, Irvine, Orange, California.

Abstract

The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a potential use of anti-aging agents in bladder cancer chemoprevention. Rhodiola rosea, growing in high altitude or cold regions of the world, has been reported to have anti-aging effects in Drosophila. We demonstrated that a R. rosea extract and one of its bioactive components, salidroside, inhibited the growth of bladder cancer cell lines with a minimal effect on nonmalignant bladder epithelial cells TEU-2. Interestingly, the R. rosea extract and salidroside component exhibited a selective ability to inhibit the growth of p53 knockout primary mouse embryo fibroblasts (p53-/- MEFs) compared to their wild-type counterparts. The growth inhibitory effects of the R. rosea extract and salidroside were, however, attenuated in TSC2 and p53 double knock MEFs (TSC2-/-, p53-/- MEFs), suggesting that TSC2 protein is, at least in part, required for the growth inhibitory effects of the R. rosea extract and salidroside. The R. rosea extract and salidroside treatment of UMUC3 cells resulted in an increase of AMP-activated protein kinase (AMPK)-a phosphorylation and a decrease of 4E-BP1 phosphorylation, leading to increased binding of 4E-BP1 to m7 GTP. These results indicate that the R. rosea extract and salidroside inhibit translation initiation. Furthermore, both the R. rosea extract and salidroside treatment of UMUC3 cells caused a significant percentage of cells undergoing autophagy. Therefore, the R. rosea extract and salidroside deserve further study as novel agents for chemoprevention of bladder carcinogenesis. Mol. Carcinog. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID: 21520297 [PubMed - as supplied by publisher] PMCID: PMC3144985 [Available on 2012/10/22]

Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers

Zhang-jin Zhang, Yao Tong, Jun Zou, Pei-jie Chen and Ding-hai Yu

CHINESE JOURNAL OF INTEGRATIVE MEDICINE

Volume 15, Number 3, 177-183, DOI: 10.1007/s11655-009-0177-x

Abstract

Objective: To determine whether the ingestion of a herbal supplement called Rhodiola-Gingko Capsule (RGC) would enhance the endurance performance of healthy volunteers and change relevant hormones in a favorable manner.

Methods: Seventy healthy male volunteers (age ranges from 18 to 22 years old) were randomly assigned to RGC group (35 cases, each capsule containing 270 mg herbal extracts, 4 capsules per day) or placebo group (35 cases, equivalent placebo preparation) for 7 weeks using computerproduced digital random method. The endurance performance, serum testosterone and cortisol levels were measured at the baseline and the endpoint.

Results: Sixty-seven subjects (34 in the RGC group and 33 in the placebo group) completed a 7-week treatment. The RGC group displayed a significantly greater baseline-toendpoint increase in maximal oxygen uptake (VO2max) than placebo group in both absolute (P=0.020) and relative values (P=0.023). At the endpoint, the serum cortisol level was unchanged in the RGC group compared with the baseline, but it was significantly elevated in the placebo group (P<0.05). The endpoint ratio of testosterone to cortisol, a surrogate for overtraining and fatigue in endurance exercises, was also indifferent compared with the baseline in the RGC group, but significantly decreased in the placebo group (P<0.05).

Conclusion: The combined herbal supplement of Rhodiola and Gingko could improve the endurance performance by increasing oxygen consumption and protecting against fatigue.