MX Liver Detox Buying Guide

When it comes to finding the best liver health supplements, you certainly have plenty to choose from. If you take the time to check out the different products that are available, it should be quite simple for you to choose the one that is most effective. Look at the ingredients that are included and the quality of the products, like those found in MX Liver Detox by Maxalife. We have a commitment to creating 100% natural supplements that everyone can enjoy, no matter what. Keep reading to learn more about liver health and buying the right supplements

Tips for Maintaining Liver Health

Avoid excessive drinking because alcohol is a known cause of liver disease

Change your diet by eating less fatty foods and more whole grains, fruits and vegetables

Use herbal supplements to support liver health like MX Liver Detox

Get rid of excess weight, as obesity is a known cause of liver damage

With these tips in mind, it should be easier to maintain proper liver health and live a healthy, active life with a liver that you can rely on for many years to come. By taking care of yourself now, you can reap the benefits later.

Amazing Liver Disease Statistics

Liver disease is currently the only leading cause of death increasing year after year

Liver disease deaths have increased by more than 12% in just five years

More people die from liver disease than car accidents and diabetes

Alcoholism and hepatitis are the leading causes of liver disease related death

Health Benefits from MX Liver Detox

MX Liver Detox provides you with many different health benefits, no matter what you might be looking for. It can help cleanse and detoxify your liver while also offering other health support. This product can provide you with many more health benefits than you might expect, including things like:

Increase digestive health
Adrenal gland support
Better metabolism
Liver damage repair
Reduction in symptoms and signs of liver disease or damage
Immune support

Why MX Liver Detox Works

MX Liver Detox works because we have taken the time to research the ingredients and study the best formulas for optimal liver health. At Maxalife, we understand the importance of winning combinations, which is why we take each supplement for what it is and do our best to ensure that it is the most complete and effective as it can be, all while keeping it 100% natural and pure so that your body can get the most nutrients possible from easily absorbed ingredients. Our unique formula in MX Liver Detox is effective because:

-Supplementation is the key to a healthy life. No one can be perfectly healthy 100% of the time, which is where our supplements come in. they can fill in the gaps and give you back the health that you deserve.

-Maxalife is committed to providing the safest and most effective supplements, which is exactly what you get from MX Liver Detox. It has everything that you need and nothing that you don’t.

-By providing necessary nutrients that the body needs, MX Liver Detox ingredients are proven to support good liver health and other related health issues.

Why Buy from Maxalife?

Maxalife products are always created with you in mind. Our company was founded by people who are passionate about healthy living and finding natural solutions for health issues. Every supplement that we create is made from the purest and most natural ingredients so that you get everything that you need and nothing that you don’t. Maxalife’s Liver Detox formula has been carefully created to be 100% natural, providing only the extra boost of nutrients that your body needs and nothing else.

When you buy from Maxalife, you will also enjoy our 6-month, 100% money-back guarantee. We understand that these supplements take time to work, and we’re willing to let you wait and see what happens. You will appreciate the benefits that you receive from products like MX Liver Detox over time, and if you don’t you can send them back for a full refund. You aren’t risking a thing when you buy from us because you’ll get high-quality supplements that are proven effective and a guarantee for any situation that causes you to change your mind about the products that you have purchased. When you purchase Maxalife products, you’re getting the best of everything for an affordable price, and that’s why our company is the best for natural supplements.

Purity and Freshness

MX Liver Detox and other supplements from Maxalife are created from 100% pure and natural products. We guarantee purity and freshness with all of our products, no matter what you might be looking for. Don’t just take our word for it, though. We have evidence to support our freshness and purity standards that will demonstrate just how safe and effective our supplements can be.

What Makes Maxalife MX Liver Detox So Beneficial?

Maxalife MX Liver Detox has everything that you are looking for in a great supplement. You will enjoy the 100% natural, pure and fresh ingredients that we combine to create the perfect balance of liver support along with other health benefits. You are getting a supplement that is natural and effective from a company that is committed to providing only the best for their customers. Plus, all of this is backed by our unmatched 6-month, no questions asked guarantee, which gives you the peace of mind that MX Liver Detox can give you exactly what you need.

Other Resources

American Liver Foundation

Doctor Yourself- Liver Health

Mayo Clinic

Purity

See Notes

Freshness

See Notes

Bio-Availability

Maxalife has a commitment to providing health supplements with the best possible bio-availability. Bio-availability refers to the rate at which nutrients are absorbed by the body. If nutrients are not absorbed well enough, they can be virtually useless to the body. People often discuss bio-availability as a critical part of choosing supplements and vitamins, and for good reason.

While our MX Liver Detox is ideally designed to offer liver health support and an overall balance in your body’s health, this would not be possible without the highest rate of bio-availability. We have specially formulated all of our products, including our multi-vitamins, to be the most effective in terms of absorption to ensure that your body gets the full support that it deserves from our supplements. While some companies sell natural supplements that are actually synthetic forms and others sell ‘sufficient’ natural supplements with moderate bio-availability, Maxalife is committed to providing only the best products with the best absorption rates for all of your health needs.

Don’t Mess with Nature

Nature always knows best, and we understand that. Our products are not intended to try to improve nature or make things work better or faster. We simply take pure elements and incorporate them into pure supplements that create combinations that will give you the health benefits that you need at a maximum level of effectiveness. No chemical process or special formulation with added synthetics could make your body more likely to absorb the nutrients from our products and we let nature do its job by providing the freshest, purest ingredients so that your body can maximize bio-availability with MX Liver Detox and other supplements that we have created.

Pharmaceutical Grade

This is a word that some companies use in an attempt to dupe people into actually thinking that there is something better out there. When you see advertisements or products that claim to be ‘pharmaceutical grade’, you need to beware. There is no such thing in the world of supplements. The best that you can get is a 100% natural, safe and effective supplement product. Marketers who are trying to aggressively corner the industry use words like this to entice people into thinking that they are getting something better than they might get anywhere else. The reality is that their products usually aren’t even the best supplements on the market.

At Maxalife, we are committed to helping people live full, healthy lives and all of our supplements are created with that commitment in mind. We use 100% natural ingredients that are pure and as fresh as possible so that you can get the most from your supplements. We don’t need to give them a fancy label or call them something that they aren’t because we create the safest and most effective supplements and stand behind every single product that we sell.

What about Regulatory Guidelines?

There are regulatory guidelines out there, but they are way too lenient and not nearly high enough to meet our standards. Maxalife is fully focused on raising the standards of quality in the supplement world, and you can trust that you are getting the best products available when you buy from Maxalife. Because of the largely un-monitored and inconsistent guidelines that are set forth by different agencies, we have given ourselves the demand of producing high-quality supplement products that go above and beyond the ‘regulations’ as they currently stand.

At Maxalife, we perform extensive testing to ensure that our supplements are the best that they can be and we keep all of our data on file so that we can keep track of how things are doing. If you every want to see just how serious we are about quality and purity, just ask.

Specifications and COA

See Notes

Benefits and Clinical Studies

MX Liver Detox includes many ingredients that have shown promise in helping cleanse the liver and promote better support for adrenal function, the immune system, and digestion. Liver support comes from Silybum marianum fruit extract, commonly known as Milk Thistle, as well as other ingredients that have proven quite effective.

Clinical Studies

Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C

Adam Gordon1, Daryl A Hobbs2, D Scott Bowden3, Michael J Bailey4, Joanne Mitchell1, Andrew JP Francis2, Stuart K Roberts1,*

Abstract
Background/Aims: ?ilybum marianum is an herbal preparation commonly used by subjects with chronic hepatitis C (CHC). The aims of this pilot study were to assess the efficacy and safety of S. marianum on serum hepatitis C virus (HCV) RNA, alanine aminotransferase levels and well-being in patients with CHC.

Methods:?wenty-four subjects with CHC were enrolled into a randomized, double-blind, placebo-controlled, crossover study. Subjects received 12 weeks of S. marianum (either 600 mg or 1200 mg/day) and placebo separated by a 4-week washout interval. Baseline biochemical, virological, psychological and quality-of-life tests were performed, with biochemical tests repeated monthly, and HCV RNA titer and quality-of-life and psychological assessments repeated at the end of both treatment periods.

Results:?eventeen patients completed the trial. Mean changes in HCV RNA titers, serum ALT levels and Short Form-36 scores were not significantly different for subjects on S. marianum compared to those on placebo. There was no significant change in mean State-Trait Anxiety Inventory State-Anxiety scores on S. marianum from baseline. Adverse events were similar with S. marianum and placebo.

Conclusions: ?. marianum is well tolerated in subjects with CHC, but does significantly affect serum HCV RNA, alanine aminotransferase levels, quality of life or psychological well-being in subjects with this condition.

The Clinical Utility of Milk Thistle (Silybum marianum) in Cirrhosis of the Liver

2002, Vol. 2, No. 2, Pages 11-17

Joel BoerthClinical Assistant Professor Psychiatric Pharmacy Resident1 and Kathryn M. Strong2
F. U. Alakbarov is Head Scientific Officer, expert in the Oriental and Folk Medicine, Institute of Manuscripts of the Azerbaijan Academy of Sciences, 8 Istiglaliyat str., Baku, 370001, Azerbaijan.
At the time of writing Liya Davydov was PharmD candidate, College of Pharmacy and Allied Health Professions, St. John's University. Currently, she is Pharmacy Practice Resident, Mount Sinai Medical Center, New York, NY.
Ila Mehra Harris is Assistant Professor, Department of Pharmaceutical Care & Health Systems, College of Pharmacy, and Clinical Assistant Professor, Department of Family Practice & Community Health, Medical School, University of Minnesota, Minneapolis, MN.Colin J. Briggs is Professor of Pharmacy, Faculty of Pharmacy, University of Manitoba. Recently he completed a secondment to Health Canada, as Senior Science Advisor in the Therapeutics Products Programme with special responsibility for complementary medicines.
Gemma Briggs is Research Assistant, IMPACT, The Injury Prevention Centre of Children's Hospital, 501G-715 John Buhler Research Centre, Winnipeg, MB, Canada.
Mary Chavezis Professor of Pharmacy Practice, Director of Complementary Medicine Education and Research, The Center for the Advancement of Pharmacy Practice, Midwestern University, College of Pharmacy Glendale, Glendale, AZ 85308.

Milk thistle (Silybum marianum) is a flowering herb utilized for its potentially protective effects on the liver. Although the mechanism of action is not fully understood, one explanation may be that it concentrates in the hepatocytes and competes with toxins for hepa-tocyte binding and penetration. Preliminary clinical evaluations of milk thistle for cirrhosis of the liver indicate potential benefits in healthier patients with alcoholic cirrhosis. However, major flaws in many of the studies make it difficult to draw solid conclusions. Milk thistle appears to be relatively safe, even with long-term use.

Inhibitory Effects of Silibinin on Cytochrome P-450 Enzymes in Human Liver Microsomes
Svane Beckmann-Knopp1, Stephan Rietbrock1, Roland Weyhenmeyer2, Ronald H. Böcker3, K. Tobias Beckurts4, Werner Lang2, Miriam Hunz1, Uwe Fuhr1,†

Abstract:
Silibinin, the main constituent of silymarin, a flavonoid drug from silybum marianum used in liver disease, was tested for inhibition of human cytochrome P-450 enzymes. Metabolic activities were determined in liver microsomes from two donors using selective substrates. With each substrate, incubations were carried out with and without silibinin (concentrations 3.7–300 ?M) at 37° in 0.1 M KH2PO4 buffer containing up to 3% DMSO. Metabolite concentrations were determined by HPLC or direct spectroscopy. First, silibinin IC50 values were determined for each substrate at respective KM concentrations. Silibinin had little effect (IC50>200 ?M) on the metabolism of erythromycin (CYP3A4), chlorzoxazone (CYP2E1), S(+)-mephenytoin (CYP2C19), caffeine (CYP1A2) or coumarin (CYP2A6). A moderate effect was observed for high affinity dextromethorphan metabolism (CYP2D6) in one of the microsomes samples tested only (IC50=173 ?M). Clear inhibition was found for denitronifedipine oxidation (CYP3A4; IC50=29 ?M and 46 ?M) and S(?)-warfarin 7-hydroxylation (CYP2C9; IC50=43 ?M and 45 ?M). When additional substrate concentrations were tested to assess enzyme kinetics, silibinin was a potent competitive inhibitor of dextromethorphan metabolism at the low affinity site, which is not CYP2D6 (Ki,c=2.3 ?M and 2.4 ?M). Inhibition was competitive for S(?)-warfarin 7-hydroxylation (Ki,c=18 ?M and 19 ?M) and mainly non-competitive for denitronifedipine oxidation (Ki,n=9 ?M and 12 ?M). With therapeutic silibinin peak plasma concentrations of 0.6 ?M and biliary concentrations up to 200 ?M, metabolic interactions with xenobiotics metabolised by CYP3A4 or CYP2C9 cannot be excluded.

Abstract

In acute liver failure following hepatitis, toxic insults, or after major liver surgery, there is an increased bacterial translocation from the gut. This may explain some of the infectious complications seen in these conditions. To elucidate mechanisms and find possible preventive measures, we investigated the effect of rectal administration of arginine and probiotic bacteria (Lactobacillus spp.) on bacterial translocation and the extent of liver failure. Sprague-Dawley rats were used and five different Lactobacillus strains (Lb.) reuteri R2LC, Lb. rhamnosus DSM 6594 (= strain 271), Lb. plantarum DSM 9843 (= strain 299v), Lb. fermentum 8704:3 (= strain 245), and Lb. reuteri (= strain 108) were administered rectally once daily for 8 days with and without 2% arginine. Acute liver injury (ALI) was induced on the eighth day by intraperitoneal injection of D-galactosamine (1.1 g/kg body weight), and samples were collected after 24 and 48 hours. Bacterial translocation was evaluated by bacterial culture from portal and arterial blood, mesenteric lymph nodes, and liver tissue. Liver enzymes and bilirubin were evaluated in the serum. The bacterial load in the cecum and colon was determined and the liver histopathological changes were studied. There was no mortality at any time. The liver enzymes and bilirubin decreased in some of the groups supplemented with lactobacilli with and without arginine compared with the ALI control group. The incidence of bacterial translocation and the number of the translocated bacteria decreased significantly in some of the supplemented groups. Lb. plantarum + arginine administration significantly reduced the level of the released liver enzymes, hepatocellular necrosis and inflammatory cell infiltration, bacterial translocation, and the number of Enterobacteriaceae in the cecum and colon. Rectal administration of different Lactobacillus strains with and without arginine in an ALI model significantly modulates the extent of the liver failure and reduces bacterial translocation. Lb. plantarum DSM 9843 (= strain 299v) with or without arginine seemed superior to the other Lactobacillus strains. The beneficial effect of arginine administration alone indicates a possible role of nitric oxide and polyamines in this process, and the lactobacilli may execute their action via the same mechanisms or via bacterial antagonism and/or enhancement of systemic and intestinal mucosal immunity.